Targeting cancer metabolism: a therapeutic window opens

Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?

Cells that have undergone an oncogenic transformation have an altered metabolism compared to the cells they originate from (1). This observation led to the addition of “a deregulated metabolism” to the hallmarks of cancer (2). Accordingly, it has been extensively demonstrated that many of the observed alterations in the metabolism of cancer cells are important for their proliferation (1, 3, 4)....

Electron spectroscopy: a new window opens.

Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer

PPARs are ligand activated transcription factors. PPARγ agonists have been reported as a new and potentially efficacious treatment of inflammation, diabetes, obesity, cancer, AD, and schizophrenia. Since cancer cells show dysregulation of glycolysis they are potentially manageable through changes in metabolic environment. Interestingly, several of the genes involved in maintaining the metabolic...

Back to the Future: Therapeutic Targeting of Cancer Cell Metabolism.

An introduction by Raymond Gilmour (Discovery Oncology Research, Lilly Research Laboratories, USA) and Susana Velasco (Cell Signaling Therapies, Centro Nacional de Investigaciones Oncológicas (CNIO), Spain) notes that with new tools and technologies in place, cancer metabolism has become an area of renewed focus for both basic research and drug discovery efforts. The ability to link genetics wi...

Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window.

OBJECTIVE To investigate the hypothesis that newly formed wound biofilms (or bioburdens) are more susceptible to antimicrobial treatment. METHOD Four separate and distinct models were performed by four separate biofilm research laboratories to evaluate the resistance of biofilms to antimicrobial treatments over time. These included a drip-flow biofilm model along with a hydrodebridement study...